Endocrine Abstracts

Nerve growth factor (NGF) belongs to the neurotrophic family and maintains the normal function of peripheral sympathetic and sensory neurons. NGF can synthesize locally in the neuronal and nonneuronal tissues. The main cell sources of NGF restrict to bone-marrow derived cells (lymphocytes, mast cells, eosinophils, monocytes, macrophages) as well as to structural cells (fibroblasts, epithelial cells, smooth muscle cells, adipocytes, keratinocytes). The sympathoadrenal activity ...

Type 2 5’-deiodinase (DIO2) is a common enzyme between thyroid and eye muscle tissues involving in T4 conversion to T3. The role of DIO2 has been demonstrated in the development of skeletal muscle. Increased DIO2 activities was connected to eye muscle enlargements in hyperthyroid Graves’ ophthalmopathy. In this study, the presence of antibodies against human eye muscle tissue fractions with the binding to DIO2 peptide was investigated and measur...

Th17 cells represent newly discovered CD4+T cells producing predominantly IL17A cytokines, which are involved in inflammations and autoimmune diseases. Elevated IL17 levels were demonstrated in thyroid autoimmunity and the activity of Graves’ ophthalmopathy. The relationship among IL17A, anti-thyroid antibodies, smoking, and clinical activity score of ophthalmopathy was investigated in hyperthyroid Graves’ disease. One hundred and thirty-eight patients, 62 with Grave...

Proinlfammatory cytokines, such as interleukin 17 (IL17) are involved in different inflammatory events causing cardiovascular diseases, osteoporosis and/or infertility. 1,25-dihydroxyvitamin D3 (vitamin D3) plays an immunomodulatory role and therefore, vitamin D3 deficiency can propagate the development of autoimmune diseases, infections and cancers.The effect of vitamin D3 on proinflammatory cytokine levels, s...

Adipose tissue acts as a metabolically dynamic endocrine organ secreting several hormones, cytokines, chemokines and growth factors. Resistin plays a role in inducing insulin resistance and inflammation mediated by IL6 and MCP1 cytokines. Polycystic ovarian syndrome (PCOS), pituitary adenoma (PA) and obesity disorders are characterized by insulin resistance and different hormonal-metabolic processes.The increased occurrence of proinflammatory IL17, IL6 a...

Postmenopausal osteoporosis is characterized by lower bone mass, loss of structural integrity, and sometimes becomes life-threatening. The development of postmeno-pausal osteoporosis is multifactorial. Estrogen plays a preventing role in the bone resorption inhibiting the secretion of proinflammatory IL1 and TNFα cytokines. IL17 proinflammatory citokine is a new candidate in the pathogenesis of osteoporosis. IL17 levels are increased in estrogen deficiency.<p class="a...

Antithyroid drugs represent mainly the first choice therapy in hyperthyroid Graves’ disease. Their therapeutical ineffectiveness can lead to the onset or the severity of ophthalmopathy associated with Graves’ disease. Type 2 5’-deiodinase enzyme (DIO2) plays a crucial role besides type 1 5’-deiodinase enzyme in the development of Graves’ hyperthyroidism. Anti-thyroid drugs inhibit the activity of both type 5’-deiodinases blocking the synthesis of ...

IL17 proinflammatory cytokine through T cell activation has prominent bone-wasting effect. Our previous results highlighted the role of IL17 in postmenopausal osteoporosis. To demonstrate the HLA allele association with the increased IL17 levels in postmenopausal osteoporosis was the object of the study.HLA class I and II alleles were measured in 64 postmenopausal women (in four subgroups: with low IL17 (1, 3) and high (>3.04 pmol/l) IL17 levels (2, ...